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I believe it depends on the medication . Look it up on google. Thats where I got my information before the Dr. told me. I'm going to be taking zoledronicZoledronic acid acid which is for osteoperosis. It comes in pill form as well as infusion , but since my bone loss is so severe I will be taking the infusion which can be done every two weeks, every six months, or once a year,which is the one I will be taking. The Dr. explained it all to me even though I already knew because of google. (hope this info. helps) cat33