i am on embrel and it can also give you leg cramps. I do get the cramoing sometimes for a day or two after the enjection. With the embrel the cramps do go away. I also take arava so maybe the combination of the drugs. Hope it it gets better. sheraf61
I hate when the treatment is painful too! Pain is listed among the side effects of Humira and this could be it. Also, since it iwas your first time to give yourself a shot, here are some pointers I found online.
"...you should always position injections at least 1 inch from recently used injection sites and avoid injection into tender, bruised, red, or hard areas. When you administer the injection you may pinch the area up when giving the injection (I hope that makes sense) Also you may want to apply a cool compress afterwards. This may help decrease injection site discomfort."
That said, if this does not work out for you, I hear that enbrel stings but is not painful.