Non-bacterial meningitis can be very difficult to diagnose. You are already being treated for most viral causes with the
acyclovirAcyclovir
Acyclovir sodium
Acyclovir topical. There are variety of tests to consider to pin down the cause.
The CSF should be sent for viral cultures and bacterial culture (in addition to the routine CSF studies). Depending upon the clinical presentation and availability of a reliable and prompt diagnostic laboratory, HSV or enterovirus PCR may also be useful. Other tests to consider include: serum and CSF Venereal Disease Research Laboratory (VDRL), HIV antibody or RNA testing, Lyme serology, and acute/convalescent serologic testing for specific viruses (LCM, mumps, measles).
If those tests are negative, more specialized testing can be considered. Evaluation should include a repeat CSF analysis with removal of large volume of fluid (3 to 5 mL, if possible) for fungal and mycobacterial cultures. Imaging of the CNS and sinuses should be performed with magnetic resonance imaging (MRI) or computed tomography (CT).
An infectious disease referral should be considered for another opinion.
Followup with your personal physician is essential.
This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.
Thanks,
Kevin, M.D.
Bibliography:
Johnson. Aseptic meningitis. UptoDate, 2004.