Oh, Carrie, I do not take the clonidine any longer but have been on Robaxin, Zoloft, & lyrica for years. I get no sleepiness, etc from any of these together or alone. ( just an FYI )
Thanks for your response. I quit the tramadol immediately after having a reaction of confusion and feeling off. I do feel much better, thank you. I will be bringing this up to my physician at my next appointment in a couple weeks. He did, however, explain this to me that an interaction could occu & to seek medical attention immediately. However, and I am extremely upset about this, the pharmacist never mentioned a word and I have been using the same pharm for years. I'm sorry, but as far as I am concerned, the info given with your meds is not enough.....most people don't read that info since they "trust" their doctors completely. I'm sure you know what I mean.
Anyway, thank you....I did not seek medical attention as the S&S just appeared and was not grave. I knew to stop the medication and stopping just the tramadol would be enough at that time. However, had the symptoms persisted after stopping that med then I would have gone to the hospital as I know Zoloft & tramadol, in this case, should have both been stopped.
Dear NurseTracy:
I apologize for the delayed response. I hope you are feeling better since your last post. It sounded concerning, and I hope your condition had improved.
You are correct about there the MAJOR drug interaction between tramadol and sertraline (Zoloft). Please note that there are several moderate drug interactions with your medications, for example, sertraline (Zoloft), pregabalin (Lyrica), clonidine, and methocarbamol (Robaxin) all can increase side effects such dizziness, drowsiness, and impaired thinking and judgment when taken together. It would be a good idea to review your medication regimen with your provider and pharmacist.
From the package insert of tramadol, under serotonin syndrome risk:
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"The development of a potentially life-threatening serotonin syndrome may occur with the use of tramadol products, including tramadol hydrochloride, particularly with concomitant use of serotonergic drugs such as SSRIs, SNRIs, TCAs, MAOIs, and triptans, with drugs which impair metabolism of serotonin (including MAOIs), and with drugs which impair metabolism of tramadol (CYP2D6 and CYP3A4 inhibitors). This may occur within the recommended dose (see CLINICAL PHARMACOLOGY, Pharmacokinetics ).
Serotonin syndrome may include mental-status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination) and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea).
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If you are still symptomatic, please seek medical assistance right away. Serotonin syndrome may be life threatening. You know your body best. So, if you are not feeling well, you need to speak up and seek support.
Good luck and take care!
For more information, please go to:
1. Serotonin Syndrome - Medline Plus
http://www.nlm.nih.gov/medlineplus/ency/article/007272.htm
Tramadol - Daily Med
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=052d06ef-4186-4ac1-9099-af05fa37c2f8#warnings_serotonin
2. Sertraline - Daily Med
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a8b2ad71-cfdc-4a29-8194-deefea138b16