Drowsiness (up to 40%)is the most common side effects of trazodone. Other CNS effects include confusion (5%), dizziness (25%), lightheadedness (25%), nervousness (up to 15%), fatigue (9%), and headache (15%). Some CNS side effects occur during the first few weeks of therapy, and tolerance can develop after 1 or 2 weeks. Taking trazodone during a fasting state may increase the incidence of these effects.
Peak levels are achieved 1 hour after dosing in the fasting state and 2 hours after dosing with food. There is wide individual response. Most patients who respond to therapy with trazodone do so by the end of the second week of therapy.
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Jennifer R RPh www.drugstore.com
Jennifer R RPh www.drugstore.com