There have been studies that show omeprazole reduces the clearance of diazepam. 'Reduced clearance' basically means it may cause the drug to be cleared out of a patient's system more slowly, which can cause the drug's effects to last longer. While alprazolam has not been mentioned in these studies, it is in the same drug class as diazepam, so the potential for a similar interaction exists when taking alprazolam plus omeprazole.
To summarize: omeprazole may potentially increase the effect of alprazolam. You should notify your physician if you notice any side-effects from alprazolam, or if it seems the drug is lasting longer than expected.
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