should i be taking these at different times of day. i usually take both together in the morning along with metformin and an asprin. i have been feeling very tetchy and tense over the past few months and i now have a very short fuse and i am very intolerant of people in general. this is a problem as i am normally the most placid person on the planet. are these tablets affecting me in some way. many thanks in advance for any help.
The only reason to take the blood pressure medications at different times during the day are if people are having problems with their blood pressure dropping too low when taking both together (usually manifests as dizziness upon standing or changing position) or if they are having issues with blood pressure control throughout the day. The only listed side effects of atenolol affecting the central nervous system are dizziness, fatigue, insomnia, lethargy, confusion, mental impairment, depression, headache, and nightmares and are listed at a frequency of 1-10% of patients. Lisinopril has a listed side effect of mood changes (1 among a long list of rare effects) in <1% of patients. Both of these side effects are extremely rare and most likely not the source of your mood changes but could potentially be contributing. It is important that you do not immediately stop taking either of these medications because it is important to control your blood pressure due to your medical problems; having blood pressure control is very important long term to prevent damage to some of your vital organs. Some options you have are changing the time of day you take the medications (maybe taking one in the morning and one at night) to see if that resolves your problem. Or the alternative is talking with your doctor to see if changing you medications is possible.
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