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Neurology
What is the latest on neurological explanation of AS (be as technical as you want)? Is there any clinical treatment for adults with AS (like SSRI for depression) that work significantly better than placebo?

Talk-therapies with impressive names are generally useless, as they are with most common "psychological" ailments. I have not heard many people say that their therapist had "cured" them before their insurance money ran out!
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There is no cure for Asperger's Syndrome.  Most of the therapy is cognitive bahavioral therapy where they basically work at teaching the proper social behaviors to children and I guess some adults.  Anyway, most drugs are given to treat co-mobid conditions such as anxiety, depression and tics.  None of the drugs have any affect on the neurological wiring.

Social group therapy has proven to be a bust.  NYU totally abandoned it a couple of years ago.  They still recommend it for its social value as sometimes the children make friends in these groups - but they are clinically insignificant as the  behavior does not carry from the specific (meaning that specific social group) to the general ( being in a new social group.  If that is what a parent is hoping for then it is a total waste of time.

Many researchers are moving towards genetics and environmental triggers. The latest is too much testosterone in the uterus or the selective mating (all of a sudden the engineer is marrying another engineer instead of the cute receptionist).  

There do seem to be some differences with Aspergers and more run of the mill autism - which is also a hot debate whether they should all be classified as autism or should Aspergers been seen as a separate syndrome.  Even though many researchers like Tony Atwood's work - the jury is not out on this one.  


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