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Looking for treatments for OPCA
Hello.  I am a 28 year old male with Olivoponto cerebellar atrophy and a dandy walker malfoemation of my cerebellum.  Only my gait and legs are noticably affected--and just my coordination.   They are currently screening my DNA for SCA 5 and 26.  My mother also has OPCA.

I am here to find a treatment.  The mantra "there is no cure, only relief of symptoms"  is BS.  It is BS because progress is being made eyery day.  

anyway, I found several peer-reviewed articles that mentioned a deficciency (sp) in dehydrogenase within the brain...

Cerebellar α-Ketoglutarate dehydrogenase activity is reduced in spinocerebellar ataxia type 1
http://onlinelibrary.wiley.com/doi/10.1002/ana.410350519/abstract

and another

Multiple system degeneration with glutamate dehydrogenase deficiency: pathology and biochemistry.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC488324/

as I understand, glutamate dehydrogenase is an enzyme... is there a spieces of probiotic (bacteria) that produces it?  how about Lactobacillus plantarum ?
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Avatar_universal
hi leolibby,

it is nice to meet you. This forum has just beeen added recently and not much activity yet.  it  looks      like you  have donne research that is over my head today:)

I dx   changes through the years since the genetics has not been pos. I have ms and some type of cerebellar ataxia . My cerebellum is atrophying  also.
I have been offered and tried different treatments(for symptoms) through the years. So far unfortunately none have   seemedto help or given relief.

II just wan tot o say hi and hope you are feeling ''well' today
take  care,  amo

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