Medication question

I am 46 years old and have recently been identified as high functioning autistic with severe anxiety.  I have been through all of the types of antidepressants over the past 20 years (some of them 2 or 3 trials) except for the tricyclics and MAOIs.  I have not had any luck with anything helping the anxiety so far, including large doses of SSRIs, in fact every one I have tried either had no effect or made the anxiety worse.  I do not like Benzos as they make me too forgetful.  I am currently on 20mg of Zyprexa but am barely functioning from the sedation.

My question is, I have read that Clomipramine, Desipramine, Nardil and Parnate can be helpful to someone on my spectrum.  Is there a chance they could help even though SSRIs have not been helpful in the past?  Is it possible to have a serotonin dysfunction?

[Richard B. Graff, PhD, BCBA-D]

Although some readers may provide comments related to their own personal experiences with some of these medications, this question is beyond the scope of practice of any of the individuals who respond to questions in this forum.  It really should be answered by a psychaitrist who has expertise working with individuals with autism.  I wish you good luck in your search for an answer.