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30 yo female with sudden onset of new symptoms and new pos hla-b27 and ...
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30 yo female with sudden onset of new symptoms and new pos hla-b27 and sed rate at 23

5710268?1274539931
I am a 30 yr old female. I weigh 122 last time at the Dr office ( last week). I had lost 10 lbs in a week by the way. I went back so soon to see her due to sudden onset of my heart skipping and my hr shooting up when I stand. My mother is a paramedic and said it sounds like pvcs. I was taking adderall (adderrall) 20 mg and she took me off and put me on Nuvigil. She only put me on another stimulant due to sudden drowsiness. So bad I didnt have the energy to do anything except go to the bathroom and eat a little. I was also taking Tramadol for my back. I have a 6mm disc herniation in S1. Also started having pain between my shoulder blades for about 5 mo that feels like it needs to pop but wont no matter what I do. Also have severe neck pain. Anyway, The pvcs went away some but yesterday they started full swing again. even when resting. My bp is normal. Avg at 125/76. Today everything the same but my hr has been at 102 and 103 all day. Even at resting. I am not really having any stress so i dont understand. EKG was normal as of 4-21-10. I also previously had thyroid cancer that was removed and I take 100 mcg levothyroxine. My question is.. What could be going on with me heart? I do have some gastro problems that affect my heart when I have a bm. I have so many health issues at the moment anyway that I dont want to add another one. Oh My Dr also just informed me that my auto immune panel came back with pos for HLA-B27 and sed rate was 23. Rheumatoid factor was neg and c protein was normal and ana was normal. I do smoke but am working on quiting. I have been having problems with my hands now for a week. Lots of pain in my joints and dropping things at times. as well as my fingers locking up. Any insight on my heart would be great as well as the pos hla-b27 and sed rate at 23.

Thank you so much..
Amber


5-22-10 (update)

Still having most of the same problems but my heart rate and PVC/PAC (whatever one they were) have stopped. Recently I have been having such bad joint pain in my hands. and have lost even more weight. My menstrual cycle was very weird and it is usually normal and every 28 days like clockwork.. This time it was late and very short and my cycle blood was brown. ( sorry for the details on that). Also I have started getting nauseous and having lower stomach pain every time I eat and loose bowel movements. i am drinking a lot of water and eating more proteins and starches to help with my weight. I have almost no body fat now. Including where women should have a lil extra.. (Not happy there). I have bouts of insomnia that have lasted for 2 days without sleep. Not taking adderall (adderrall) anymore by the way. I guess my question is what is wrong with me?? I know no one can tell me for sure I am just so tired of being in pain and feeling exhausted  every day. I want to get up and do anything but cant because I have no energy. I mean none. I am either in pain from my herniated disc of joint and muscle pain or I just cant get up. I feel like Im sleepy all the time and get those headaches from laying around. You know the ones like when you slept too late of havent been outside all day and  you just feel gross and get that throbbing yuck headache.. Thats what I get. lol I am trying to just make myself get up at times because it helps some. I even get an RLS feeling in my whole body. Like all my muscles have to move at once. Could that be from not moving around a lot. Its wierd because I work 2 days a week and I am on my feet all day. I do hurt when Im there but I seem to be able to ignore it or just not do some things. But for the next week I am in so much pain that it takes me almost the whole week to recover. I dont have much choice I have to work. Disability doesnt pay all the bills. Ok my question or questions.. lol Does anyone have any ideas on how to ease my all over pain? Low cost  and that  might actually work. I have taken the narcotics and they do help but only mask the pain a little and with an injury to my S1 I really am trying to stay out from under the knife as long as I can. So I would like to stay away from them so i can listen when my back says dont do that. I have tried Lyrica but it only seemed to make me feel drunk and didnt help with any of the sciatica pain and also made me more depressed. I am taking tylenol now but I seem to be taking more and I dont want to do that either.. No need to add any liver problems to my list..( knock on wood) I have been pretty depressed lately due to the fact that I feel like a big pile of doo doo and in pain every day but I am trying to make myself do more to get out of that. Its better this week than last week. Its just my energy level. Is it possible that my weight loss could be the cause of my sudden lethargy and fatigue? What can I eat to maybe help with that? Also I was taking Cymbalta a while back before my thyroid cancer was found and removed so Should I maybe start it again? I havent been able to get back to my dr because of transportation. My truck just died on me so I am limited as to when I can go. I have had to cancel twice because my ride couldnt make it. Thats why I am asking all these questions I know I need to be asking my Dr. As well as I have not been able to get to her to get the latest blood test results on, "The Quest of Diagnosis"  lol. Im sorry to all I know I may sound like I am whining or being a baby. I just would like some relief. Or answers. Even insight. Most important I want to ease my pain. Then its the energy. Then its the weight loss and stomach issues.. In that order.. I do suck it up and move on because ther are people out there with worse pain and medical problems than me. I have to look at it like this. I am still alive and breathing and I am still able to walk and be mobile. There are many out there with an Auto Immune disease or diseases that cant anymore and would gladly trade. Im only 30. I just want to be able to feel like it for once.. My heart does go out to those who know where I am coming from and are where I am going and My issues seem like suneshine and rainbows compared to the complications of  AS, RA, Lupus, and the list goes on. My Dr did say that she was leaning towards Spondylitis. ( if I spelled it right). Ok just AS. But I am being told that it is not common in women. If it is not then with the symptoms and test results I have so far, what other possibilities are there. ( Pos HLA-B27, Elevated SED rate at 23, RF neg C Protein Normal, and ANA Neg). I am hoping it isnt AS. I have a friend whos 5 yr old has AS and I see what he is going through and her husband has it as well and he has so many other HLA Associated  autoimmune disorders developed later in life on top of it. As well as I have read others posts of all they are going through. What other tests should I possibly have her run so we can start treating something? I am 30 so that is in my favor. Again, Im sorry to be sounding like a baby I just need some relief. I want some of my life back. I also wanted to apologize  for my flipping around and going on and on. I am ADD and on taking the Adderall (adderrall) anymore so i am all over the place but Im working on that as well. Thanks to anyone who can actually sit through and read this as well as answer any of the questions thrown all over this post. If you get through to the end without clicking another post... THANK YOU. And thanx for listening to my vent..  

Amber
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434278_tn?1324709825
Hi Amber, sorry to hear about you going through so much.  Do you have medical insurance?  One of the things that can cause tachycardia is blood sugar problems.  A suggested test is the C-Peptide as well as a glucose intollerance test.  

Just because your ANA is neg, doesn't completely rule out an autoimmune.  I had several positive test, then a neg right before it jumped up to 1:2,560.  I had spent time in the sun prior to that test.

To determine whether you have human leukocyte antigen B27 (HLA-B27) on the surface of your cells; to help assess the likelihood that you have an autoimmune disorder associated with the presence of HLA-B27

Drs. test when you have symptoms of chronic inflammation, pain, and stiffness in certain areas of your body, such as your back, neck, and chest, or eyes, especially if you are male and the symptoms began in your early 30s.  

The HLA-B27 test may be ordered as part of a group of tests used to diagnose and evaluate conditions causing arthritis-like chronic joint pain, stiffness, and inflammation. This group of tests may include an RF (rheumatoid factor) with either an ESR (erythrocyte sedimentation rate) or a CRP (C-Reactive protein). HLA-B27 is sometimes ordered to help evaluate someone with recurrent uveitis that is not caused by a recognizable disease process.

Source: http://www.labtestsonline.org/understanding/analytes/hla_b27/glance.html

It also sounds like you might be having trouble w/ endometreosis.  I took an herb called chasteberry tree (Vitex).  It totally shrunk the endometrial lesions to microscopic size.  This herb also made my cycle be normal.  I had the same problem w/ my cycles that you had.  

Just to share w/ you a little bit about myself, I was dx w/ lupus and fibromyalgia about 2 years ago.  Was very sick for 1 1/2 years b4 being diagnosed.  Had fatigue, joint pain, muscle pain and weakness, tachycardia, vertigo, nausea, irritable bowel,  facial rash to name a few.
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1297728_tn?1272622169
well from what I understand from the tests done so far, I do not have lupus or ra. The dr did say that I do have some sort of an auto immune. Just not sure about anything more at the moment. Funny you post that info from labtestsonline cus I I went there the other day.. lol. As far as it being endo. I went to the obgyn a couple of months ago and had a pelvic ultrasound done and some other tests and she said that it is unlikely that i have endo so... On with my search... lol I am making an appointment in the morning to get my results of the last test run.. Thanx for your post..
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848718_tn?1257142401
Just to chime in: It's impossible to diagnose or rule out endometriosis without a laproscopy (sp). It would have to be hugely bad for it to show up on ultrasound. And the amount of pain, etc., is not necessarily related to how much endo you have. I'm not trying to say you DO have endo, but there's really no way for the OB to know without going in and looking. And your issues with GI distress can be caused by endo as well. Have you seen a gastroenterologist? While 23 isn't a particularly high SED rate, there's a number of inflammatory bowel diseases that can cause (or be linked to) joint pain elsewhere in your body. Also, have you been tested for celiac?

I know what it's like to be a mystery patient and desperately want a diagnosis. I've been sick for three years now, and while I've collected a list of secondary diagnoses, no one has figured out what my main problem is. The thing about autoimmune diseases is so many of them have the same symptoms, and most docs will tell me that they think there are many autoimmune disorders that have not yet been quantified and able to be diagnosed. Which *****, I know.

Anyway, good luck. Please let us know what you hear after your next appointment. I hope you get some good answers SOON.
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434278_tn?1324709825
I completely agree w/ sickmomma.  You cannot dx or rule out endo by an ultrasound.  A dr. must do exploritory laproscope.

I'm not a familar w/ RA as I am lupus.  I could give you a little info on lupus.

There are 11 criteria for a lupus dx.  You must have at least 4 of the 11 to recieve a dx.

They are:
1. malar rash over cheeks (butterfly rash)
2. discoid rash, red raised patches
3. photosensitivity - reaction to sunlight, resulting in skin rash
4. oral and nose ulcers
5. arthritis
6. serositis - inflamation (inflammation) of the lining of the lung or heart
7. reanl disorder - excessive protein in urine and/or cellular casts
8. neurologic disorder - seizures, or psychosis
9. anemia or low white blood count or lymphopenia or low platelet count
10. positive ANA
11. positive anti-DNA or anti-Sm, or antiphospholipid antibody or false pos. syphilis test

Other symptoms are:
fever
abdominal pain
chest pain
shortness of breath
blood in urine
hair falling out
fatigue
muscle pain and weakness
dizziness
poor memory
headaches
poor circulation in fingers and toes
tingling in extremities
diarrhea
bloating
nausea
weight loss
abdominal pain
blurred vision
depression
palpitations
raynauds (where fingers turn white when cold)
intollerance to cold
sore throat
...to name a few

Keep in mind that fibromyalgia, CFS, MS and lymes disease also have similar symptoms.  

Not everyone w/ lupus has ALL of these symptoms, and they tend to come and go.  I know your dr. will figure this out eventually.  He knows there is an autoimmune connection.  Other autoimmune diseases that affect joints are: ankylosing spondylitis, behcet's,  rheumatoid arthritis, sarcoidosis (?), Sjogren's (?), and lupus,.  Celiac can also cause joint pain and  often accompanies autoimmune diseases.  Lupus can affect every area of the entire body.  It certainly has caused problems w/ my digestive tract.  

The only advice I can give you right now is to try not to let it all get to you emotionally.  Stress will only make symptoms worse.  Just in case it is lupus, stay out of the sun as much as possible.  You won't always feel bad right away, sometimes its the next day.

Praying for you, Kara

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