Autoimmune Disorders Community
Auto Immune Disorder
Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Auto Immune Disorder

I have an Auto Immune Disorder of the connective tissue as labeled by my Rheumatologist.  I take Plaquenil 200mg, and Arava 20mg daily.  I have been on the Plaquenil for over a year and the Arava for 5-6 months.  I am still having flares and experiencing pain on a daily basis.  I'm a 28 year old male.  My tested positive for ANA but the doctor hasn't labeled me with Lupus.  I see my Rheumatologist on the 18th of December and I'm looking for the next step in my treatment.  Do you have any suggestions for what I should talk to my doctor about when I see her?  Possible treatments (Humira, Cymbalta etc.)  Thank you!
642304_tn?1242610324
Although Plaquenil was developed and has been used to treat certain infections like Malaria, its use in certain autoimmune diseases is not understood. It can reduce skin problems in lupus and prevent swelling/pain in arthritis-like conditions, though it is not known exactly how the drug works on autoimmune diseases.   My guess is that it treats one or more chronic infections that are present.

Arava is a pyrimidine synthesis inhibitor that is used in the treatment of Rheumatoid Arthritis. It is thought to work by blocking certain enzymes responsible for abnormal tissue development or growth.

If you respond to anti-infectives like Plaquenil, you could have a chronic infection like Mycoplasma.  These are often found in connective tissue and joint autoimmune conditions.  

If you have a Mycoplasma or other chronic infection, then you might respond to anti-infective drugs like oral doxycycline given long-term (These infections are difficult to suppress in the usual short-term courses of treatment that most physicians favor).  In cases like this it is usually better to add the additional antibiotic, rather than substituting for the Plaquenil.
Prof. Nicolson
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Autoimmune Disorders Community Resources
RSS Expert Activity
233488_tn?1310696703
Blank
New Cannabis Article from NORTH Mag...
Jul 20 by John C Hagan III, MD, FACS, FAAOBlank
242532_tn?1269553979
Blank
3 Reasons Why You are Still Binge E...
Jul 14 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating: What Your Closet ...
Jul 09 by Roger Gould, M.D.Blank
Top Autoimmune Answerers
434278_tn?1324709825
Blank
karajo
Spearsville, LA
1530171_tn?1362547225
Blank
TheLightSeeker
London, ON
1340994_tn?1374197577
Blank
Caryopteris
Raleigh, NC
8221281_tn?1397574572
Blank
Pantx
Denton, TX
1756321_tn?1377771734
Blank
Red_Star
Queensland, Australia
Avatar_f_tn
Blank
nutrinut_bob