Hello. I was diagnosed with Sarcoidosis in 2008 which was confirmed by biopsy. Since then I have tested positive for RA and my ANA has been as high as 1:5000 currently it is 1350 and always a speckled pattern. When I was diagnosed with the Sarc I was prescribed Azathioprine which I found out over the three years I took it has damaged my pancreas and I am left with debilitating chronic pancreatitis. My liver enzymes over the years have been elevated off and on but no jaundice just fatty liver. Because my ANA is so high and I tested positive for the RA they went ahead and tested me for lupus. The lupus came back negative but I did test positive for the AntiSmooth Muscle Antibodys which I guess means auto immune hepatitis. My question is: Is there anyway you can have a false positive? I take the following meds.
ASMA - Anti-Smooth Muscle Antibody can be seen in infectious mononucleosis & other viral infections, Systemic Lupus Erythematosus (SLE), breast & ovarian carcinoma, and melanoma. It can also be seen in about 50% of cases of primary biliary cirrhosis, alcoholic related cirrhosis, and cases of biliary duct obstruction.
At a starting dilution of 1:20, there are many false positives for ASMA at this low titre level. ASMA is found positivity in 1.2% of "normal" people under age 40 and in 3.5% over 70 years of age.
Associations with elevated levels of ASMA antibodies:
Autoimmune (chronic active) hepatitis (AIH): 50 - 80% of cases, 70% at >1:1002; >1:160 is significant serologic evidence - suspicious for autoimmune hepatitis, especially if liver biopsy contains plenty of plasma cells To note: there have been documented cases of levels >1:160 that were not AIH.
Thank you for the info the first test didn't contain a titre so I just had more bloodwork done for the titre and a repeat ana. At this point it would not surprise me one bit for it to be positive I'm just a little confused that if I am truely positive why am I not having more hep symptoms? I guess thats good I don't want to wish anymore bad stuff on me. I'll let you know how it turns out.
Hello. I got my blood tests results back and the AntiSmooth Muscle came back negative. This has everyone confused so I was asked to contact my doctor at UPenn. Because the pain I have is so massive we're going to repeat everything. The USEndoscopy, bloodwork, small bowel and I think she want's me to swallow that pill that takes pictures of your insides. I hadn't seen her in a few months and honestly I think she was frustrated because it would seem nothing would be easy to find. I have a few of the characistics of pancreatitis. Its been a year since we've done all this stuff so now maybe some new info will come to light. Still confused but hopefully some clarity will soon follow.
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