I have had several symptoms and and off for a few years of autoimmune type. I have tested both positive and negative for ANA. I have a high CH50 result (60), a high anti-dna (ds) result of 48. The sjorgrens anti ss a and b were both border at 0.2. So was rnp antibodies and smith antibodies (both 0.2). several other results were high (or low) but I'm not sure if they are relevant. (vitamin D -16.7, RBC 4.06, potassium 3.6, bun 7, globulin 4.0, AST 9sgot) 12, CRP screen 0.64)
I know you can't give me a diagnosis, but could you give me a professional opinion?
"ANAs are found in patients who have various autoimmune diseases, but not only autoimmune diseases. ANAs can be found also in patients with infections, cancer, lung diseases, gastrointestinal diseases, hormonal diseases, blood diseases, skin diseases, and in elderly people or people with a family history of rheumatic disease. ANAs are actually found in about 5% of the normal population.
The ANA results are just one factor in diagnosing, and must be considered together with the patient's clinical symptoms and other diagnostic tests. Medical history also plays a role because some prescription drugs can cause drug-induced ANAs.
Statistically speaking the incidence of positive ANA (in percent) per conditon is:
Systemic Lupus Erythematosus (60%)
- Associated with Lupus Nephritis
- Associated with Lupus CNS Involvement
- Correlates with disease activity
Sjogren's Syndrome (5%)
Rheumatoid Arthritis (<5%)
Chronic active hepatitis
Epstein Barr Virus
Vitamin D deficiency is very common. T-cells start out inactive, but once triggered they become killer cells that seek out and destroy viruses and bacteria. Researchers from the University of Copenhagen have found that T-cells will lie dormant unless they can find vitamin D. Optimal vitamin D levels are 80ng/mL or 200nmol/L.
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