A positive ANA (anti nuclear antibody) can be seen with various autoimmune diseases, as well as infections, cancer, lung diseases, gastrointestinal diseases, hormonal diseases, blood diseases, skin diseases, in elderly people, or people with a family history of rheumatic disease.
The centriole/centrosome proteins are found with Raynaud's phenomenon, scleroderma, Sjögren's syndrome, limited scleroderma (CREST), and viral infection.
Hashimoto's thyroiditis (most common cause of hypothyroidism) occurs with increased frequency with certain immune diseases including scleroderma and Sjogren's syndrome. I mention this particular condition as it is one of the causes of high uric acid.
Causes of high uric acid include diuretic medications, excessive alcohol consumption, excessive caffeine consumption, family tendency (genetics), hodgkin's lymphoma, non-hodgkin's lymphoma, leukemia, hypothyroidism, niacin (vitamin B3), obesity, psoriasis, purine rich diet (organ meat, game meat, anchovies, herring, gravy, dried beans, dried peas and other foods), some immune suppressing drugs.
Sorry, that was meant to say "(0.46mmol/L) - not sure if that makes a difference."
Also, if these are indicators of things to come, is there preventitive measures available?