I have had a positive ANA with centromere antibodies since Oct 2009. I do not present with any skin symptoms so the Mayo Center is leary to DX me with Scleroderma - although rare, they did say Since Scleroderma was a possibility. The diagnostic testing did reveal: raynauds, esophageal dysmotility (failed 30% of swallows), some delayed gastric emptying, had an esophageal dilation, of course the +ANA and + ACA. Symptoms are more rheumatological with joint pain, bouts of severe fatigue, hand pain, muscle weakness (no elevated CK), low grade fevers, arthritis in wrists, random swelling of hands and fingers. Mayo said go home till I got worse, then come back...Local rheumy said "You have Crest" and started Methotrxate due to swelling in hands. Now my most recent labs came back with a lowered Anticentromere at 3.0, an elevated Ferritin at 190, and an elevated Hematocrit at 47.... Is the ferritin directly related to an autoimmune response (acute phase reactant?) or do I need to pursue further testing? Also to note I have had a borderline hepatospleenomegaly during this period as well. With the elevated HcT do I need to pursue further testing? The rest of my ANA reflex panel is all negative, the only other oddidty is a protein gammopathy of Alpha 2....what do you think? Crest? Something else completely?
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