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False positive VDRL>>autoimmune, liver problem?
Where should we go from here? In the past three years, my son has had two VDRL tests with a "Non Reactive Rough" and a "Reactive" result respectively. A different follow up confirmation test was done in both cases and both time came back as "Non Reactive."

Because of this, we, along with his doctor, believe that for some reason he is coming up with false positives. I asked the doctor to do whatever other tests she felt were necessary to get to the bottom of what was causing the false positives.

ANA Test came back negative (.42).

On thyroid testing, T3 Uptake came back slightly elevated (38.26). T4, TSH, and FTI within normal range.

On Metabolic Panel, only results outside of normal were TBIL (1.5) and HDL (79).

On Hematology, RBC was a bit low (4.55) and MCH was a bito high (32.4).  

In follow up (because of TBIL) Hepatic Function Panel, elevated levels came back for: Albumin (5.4), A/G (2.2), ALP (122), TBIL (1.3), and DBIL (0.4). Hepatitis Acute Panel all came back Non Reactive.

A follow up sonogram of thyroid came back normal.

Sonogram of the abdomen came back with: Normal liver, gallbladder, pancreas, and kidneys. And mild splenomegaly (12 cm.).

Our question is, where should we go from here in trying to get to the bottom of his abnormal results on these tests and the false positives on the VDRL?

Thanks for any suggestions.
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Avatar universal
Many other medical conditions can produce false positive results, including some viruses (mononucleosis, hepatitis), drugs, pregnancy, rheumatic fever, rheumatoid arthritis, lupus, and leprosy.

ANA is not a perfect screening test for the Autoimmune family of these (one of the commonest false +ve causes), which can be very varied, often of very little impact.
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