There have been studies reporting either increasing or decreasing the neutrophil count with methotrexate. However, this is not a normal side effect of methotrexate.
High neutrophils are seen in acute bacterial, viral and fungal infections such as abscesses, furuncles, tonsillitis, diphtheria, otitis media, appendicitis, cholecystitis, osteomyelitis, meningitis, plague, salpingitis, and peritonitis. Neutrophilia can also occur in noninfectious conditions, such as acute myocardial infarction, burns, postoperative, acute gout attacks, acute glomerulonephritis, collagen vascular diseases, rheumatic fever, and hypersensitivity reactions.
The only explanation can be a hypersensitivity reaction to methotrexate or that you have an acute inflammatory condition. Since I cannot examine you and know other related conditions you may be having, nor is a detailed history possible on net, I have listed the various possibilities that should be looked into. Please consult your PCP for primary examination followed by proper referral. Take care!
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