3537672 tn?1429418097
Methotrexate
I am 21 years old and was just diagnosed this last November with Scleroderma. About 3-4 months ago my doctor started me on Methotrexate and this last week it was upped to 20mg every Friday. I am also on folic acid and leucovorin to help with the side effects. My issue is with how tired this makes me. The methotrexate has always made me really tired, however, since my dosage was upped I'm just exhausted.

I've slept about 32 out of the first 48 hours after I took my meds this time. I have a 7-4 desk job M-F and when I'm not working I'm either sleeping or laying in bed because I don't have the energy to get up and move around. I know there is an adjustment period  for this however I've never been this tired nor has it taken me this long to get over it. I have another dose tomorrow and if I feel the same through next week I am going to call my doctor and see what else i can do.

Does anyone else experience this? Is this considered normal for this drug? How do you cope with it or what might help me cope better? Any help is very much appreciated...
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351246 tn?1379685732
Hi!
Yes, methotrexate can cause drowsiness and this can be dose related. So, the more dose you take, the more drowsy you will be. You can talk to your doctor to see if some other immune suppressing drug like cyclophosphamide will help you. Also ask your doctor whether you can be put on steroids or not. This will help either stop methotrexate or lower its dose. Take care!
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