My ANA is nucleolar, 1:320. I have had a headache for weeks, pain in several parts of my body like neck, under my arms, waist, hands are weak, fatigue, and the list goes on... Im scared, my grandma had lupus, which is why they tested the ANA... my doctor said 1:320 was insignificant (I now know she was wrong :(...) and asked me back then about joint pain which I didn't feel at the time but I now do. Please tell me what have you been diagnosed with?