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Anticardiolipin Antibodies in the Sera of Patients with DiagnosedChroni...
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Welcome to the Autoimmune Disorders forum. Questions in this forum are being answered by Dr. Garth Nicolson. This forum is for questions and discussions relating to Autoimmune Disorders. Topics include, but are not limited to: Alzheimer’s, Amyotrophic Lateral Sclerosis (ALS), Chronic Fatigue Syndrome, Fibromyalgia, Gulf War Syndrome, Lupus, Lyme Disease, MS, Rheumatoid Arthritis

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Anticardiolipin Antibodies in the Sera of Patients with DiagnosedChronic Fatigue Syndrome'


Hi Prof. Nicolson,

I was reading a recent study that examined anticardiolipin antibodies in the sera of patients clinically diagnosed with chronic fatigue syndrome. The results of the research found the presence of immunoglobulin M isotypes in 95% of the serum samples tested (CFS patients).

I was wondering how viruses and/or bacterial infections cause these abnormalities ? I also have a high platelet count and during the last 15 years... it is getting even higher.

Thank you for joining us again !

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Anticardiolipin antibodies are found in most autoimmune disorders and especially in those that involve decreased mitochondrial function (essentially all fatiguing illnesses and many other chronic illnesses, such as neurodegenerative diseases, neurobehavioral diseases, among other diseases).  Cardiolipin is a specialized lipid that is mostly found in the inner mitochondrial membrane where it is essential for oxidative phosphorylation or the production of high-energy molecules in the cell that are necessary for metabolism and cell function.  Reduction of the cardiolipin molecules results in leaky mitochondrial membranes, and these membranes must not be leaky or high-energy molecules can’t be produced, resulting in fatigue.  Infections damage cardiolipin and other membrane phospholipids by oxidation—the infections produce peroxides that oxidize the membrane lipids, and cardiolipin molecules are particularly sensitive.  Once damaged, they must be removed and antibodies can be made against them during this process.  These same oxidative events can damage the endothelial cells lining the blood vessels, resulting in increased platelet aggregation and increased production of platelets to compensate for this.
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A related discussion, pediatric fatigue, ANA, anticardiolipin, hematuria was started.
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