I'm a 42-year old female. I'm wondering if you can tell me, should I be worried or taking an 81mg aspirin for a Cardiolipin Antibody IGM test score of 28 (Range 0-19 MPL)? My General MD didn't seem to think I needed to take an Aspirin, even though he said it wouldn't hurt. I cut my finger a couple weeks ago and bled really good. So, wondering if I should be concerened? I think my General MD is thinking I either have Lupus or could just be going into Menopause. Not sure if Menopause would cause or effect the Cardiolipin Antibody test ... but it was a thought. Thanks!
Anti-cardiolipin antibodies often show up immediately after a stroke or in patients with Lupus (SLE) or other autoimmune disorders. This can also occur at menopause. Most of our cellular cardiolipin comes from the mitodhcondria, the little energy-producing organelles within each cell of our body.
When our mitochondria are degraded, cardiolipin is released. This can happen in certain chronic conditions where mitochondria are stressed. Unfortunately, in many chronic conditions our mitochondria are stressed, and especially when intracellular infections are present that cause oxidative stress to our mitochondria. (The cardiolipin molecules in the inner mitochondrial membrane are expecially sensitive to excess oxidative stress and once oxidized they can be released from cells.)
Taking asprin would not normally be expected to have much of an effect on intracellular cardiolipin that is mostly in the mitochondria. However, asprin does affect blood clotting, which could be slightly affected by excess cardiolipin and cardiolipin-antibody complexes in the blood.
THANK YOU so much for answering me in such an explanative method! I'm not a complaining-type female and have always eat healthy and have always done "the right thing" with health and exercise. It's just that something has been bugging me "sometimes" during the past few years that no doctor in this part of the world (South Dakota) can figure out. The thing that bothers me most is my skin condition, which even a biopsy, by a Dermatologist, did not reveal anything. I've had lots of ANA tests done in the past years, all negative. The only reason I know about the Cardiolipin is because my General MD went past the standard ANA this time and ordered the sub-antibody tests, thus finding the Cardiolipin abnormality.
What you explained to me comforts me, even though I'm still a mystery, because I gather from your explanation that the one-time finding of this Cardiolipin abnormality, and such a low score, should not be of great concern, "yet". Just wanted to thank you again.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.