I,ve been married for 12 years to a woman who I have always thought to be bipolar. Major mood swings, verbal abuse, contolling and manipulative behavior, lying and an overall sense of unhappiness. I have just learned that she is being treated for thyroid disorder (hypothyroidism) and is taking Synthroid for treatment. She still acts the same as above but now even more amplified. She is so irritable and depressed that I think she might be crazy. Does Hypothyroidism relate to Bipolar Disorder ?