Tryptophan is an amino acid that brings feelings of calm, relaxation, and sleepiness apparently a precursor to 5HTP again a precursor to seretonin. I know it is sold on shelves in some countries. Apart from the classical announcement that everyone has a different reaction to each med, my question is away from antidepressants for me which are deadly (mania), does tryptophan also lead to mania because it improves seretonin which has the same effect. Or perhaps taking it in small dose (supplement) reduces insomnia.
has anyone tried it for that purpose, or people resort usually to benzo which apparently improves the GABA. Being not a doctor I am confused here.
Has anyone bought it and used it
thanks
ezz
With the tryptophan, while it is a serotonin precursor, I'm not sure there's any evidence that it would do much. The blood brain barrier keeps a lot of things out of the brain, so there's no guarantee that any serotonin made would make it on up. I don't know if tryptophan would pass the blood brain barrier in a large enough quantity to make a difference or not. My suspicion is that as long as you have enough protein in your diet, you don't need to take extra tryptophan. I doubt taking extra would make you manic.
As far as B vitamins go, most of them get peed out as excess since they're water soluble. If you take a B vitamin pill, your urine turns really yellow, and this is from excess B vitamins being peed out. I think you'll do fine with a pill if you want to do that, although I'm not sure there's any evidence that it helps with mood.
For sleep, start with sleep hygiene. Try to keep a regular schedule, even on weekends. Get early morning light exposure, or buy a light box (which does have evidence behind it for adjunctive treatment for depression). Only use your bed for sleep and sex. If that's not enough, you could go for the "Z" drugs (Ambien or Lunesta), whose generics are zolpidem and zopiclone. Some people take a low dose of Seroquel or trazodone to sleep, and they aren't habit forming. Some people take benzos, but there's more of a risk of dependence with those.