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Not bleeding after taking Mifegest

Dear Sir/Madam,
We have 22 months old twin son & daughter who are the IVF babies. My wife had LMP 12.02.2017 & subsequently did the urine test/USG/TVS on 18.03.2017. On 19.03.2017 she took Mifesterone 1 tab & Misoprostol 2 tabs on 20.03.2017. Thereafter, she administered Misoprostol 2 tabs vaginally on 21.03.2017 (today at 8 am) but she is still waiting to bleed. Please guide us in this regard.
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