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Chronic white bloode cell count 2+ years, no diagnoses, please help.......
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Chronic white bloode cell count 2+ years, no diagnoses, please help....?

I am a 44 yr white male, have smoked since late teens and have a constant high white bloode cell count that bounces up and down and back up again between ( 11k to 30k ). My other symptoms are headaches, fatigue, and daily light headedness. I have been to a hemotologyst/oncologist which took a bone marrow biopsy with negative results, also many blood test with that same high white blood cell count from 11k to 30k, no diagnosis just take more blood test. Also seeing a infectious specialist who put me on a daily IV PIC for 3 months resephin and vibative (not sure the spelling there. Blood was tested weekly while on the IV PIC and still bounced up and down, not ever getting lower then 11k, also did a stomach CT with nothing negative found. Also seen pulmonary specialist with a chest CT that resulted in 3 non calcified nodules about 3 to 4 cm I believe, told they were too small too scrape and biopsy. Second CT showed no change, white count still high. Also seen a neurologist for the head aches, did 2 brain CTs that showed nothing negative, and a neck CT that showed some issues that made him believe that was the cause of the headaches, but surgery was not needed, he prescribed 200mg Celebrex and some muscle relaxers. I have had so many blood test, cultures, CT scans with still no diagnoses, everything except a Colinosposy. Not sure why there still is no diagnoses or if I need to be worried and where to go from here. Any real help or experience with the same issues out there. Please help......
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351246_tn?1379685732
Hi!
Elevated WBC or leukocytosis may be caused by several conditions including bacterial infection, inflammation, leukemia, lymphoma, trauma, use of certain drugs (steroids, antiseizure medications), myeloproliferative disorders of the bone marrow (chronic myelogenous leukemia, polycythemia vera, myelofibrosis, essential thrombocythemia), inflammatory bowel disorders (Crohn’s disease, ulcerative colitis), burns or stress (physical or emotional).  
In your case, except for gut related disorders, all else have been ruled out. Also inflammatory conditions like chronic muscle disorder, rheumatoid arthritis etc should be looked into by an ANA test.
Did you get differential WBC count? Raised neutrophils are found in bacterial infection, raised lymphocytes are found in viral infections such as glandular fever and lymphocytic leukaemia (CLL), raised eosinophils are found in parasitic infections, asthma, or allergic reactions and raised monocyte and basophils are found in monocytic leukemia, chronic ulcerative colitis, regional enteritis and leukemia or lymphoma respectively. Monocytosis is seen in subacute bacterial endocarditis, syphilis,  viral infections, kala azar, malaria, Rocky Mountain spotted fever, lupus, rheumatoid arthritis, IBS, lipid storage diseases, sarcoidosis etc.  High lymphocytes are seen in inflammatory bowel disorders (Crohn’s disease, ulcerative colitis), leukemia, infectious mono nucleosis, tuberculosis and whooping cough. High basophil count (only basophils increased) is generally seen in allergies and worms in stool.
White cells can be tagged with a radioactive substance and reintroduced into the blood and its movement through the body is noted. This helps identify the source of infection and localization as may happen in leukemias and lymphomas. Proper diagnosis can be made by cell tagging, differential counts, symptoms, bone marrow biopsy (done in your case), etc.
Since I cannot examine you and know other related conditions you may be having, nor is a detailed history possible on net, I have listed the various possibilities that should be looked into. Please consult your PCP regarding this. Take care!
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Avatar_m_tn
I too have similar issues and remain undiagnosed. 38 year old female. Elevated white count (12,000 to 17,500) since 07 with no acute infection. Elevated neutrophils, monocytes, and basos. The differential I just has came back with "large" platelets and a liver panel revealed elevated ALK which was determined to becoming from the bone. My symptoms are  premature ovarian failure at 35 y/o, chronic fatigue, chronic diahrrea, blinding migraines, bloating, nausea, abdominal pain (upper right quad and lower left quad), unexplained extreme weight gain (85 lbs), pain to light touch, bone pain, and joint pain. I have had every test you can imagine, ultrasounds, cat scan, MRI's, upper endoscopy, colonoscopy, hepatobiliary scan, breath tests, defoscan, and more. Several "cysts" have been found but the Dr's continue to state that they are of no clinical significance. The only I am mostly concerned about is the one within my spleen which appears to be growing. It went from 1.3CM to 3.0 CM since last year. I am at a loss and I am sick and tired of being sick and tired.
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Avatar_f_tn
Vasculitis?
Get tested for Mycoplasma serology,Inflamation (inflammation) markers (ESR ,C-reative)
JSR+film
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Avatar_f_tn
I'm having the same issue. I've gone undiagnosed for almost 2 years now. My WBC was a little higher than normal at my last appointment. The hematologist told me I have sensitive bone marrow but won't do anymore tests for 6 months. My family Dr completely trusts him but I'm starting to worry
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