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Low gamma globulins and low alpha 1 proteins
I've been having a lot of neurological symptoms that wax and wane. My doc thinks they might be related to a blood condition and has referred me to a hematologist/oncologist. I was wondering what sorts of conditions might produce the following results:

SPEP - normal total protein, normal albumin, low alpha 1 protein, low beta protein, low gamma globulins. No M-spike.

Immunofixation - no monoclonal proteins present.

Anion gaps have been low going back to 2007, but only my lymphocyte % drops on occasion until this summer. I have had 2 high/borderline high blood calcium levels.

Dexa bone scan shows osteoporosis at age 43, and low vitamin D.

There have been peripheral and central lesions picked up on VNG studies, and a neuro-ophthalmologist suspected possible demyelinating disease after several exams. Symptoms responded to high-dose oral steroids over the course of 4 months.

Most of my symptoms have been attributed to complex migraines by a specialized neurologist until now because there was no other answer.

My sed rates and c-reactive proteins are typically at the very low end of normal - so inflammation of any type is not showing up in the extensive bloodwork that's been done over the last couple of years. I do suffer from severe fatigue, brain fog, and have had flareups that resemble an MS episode with weakness followed by intense muscle spasms for weeks, then they slowly disappear over the course of months. My reflexes vary from hyperactive to non-existent.

Any ideas on what a possible differential dx might look like at this point? In particular, I'm interested in hearing about any benign conditions that could cause the above, if there are any. All I can find are malignant diseases.
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Avatar universal
Saw the blood specialist who ordered a quantitative immunoglobulin test. If it's abnormal, she wants to start some CT scans. She mentioned lymphomas and thymoma. I sure would like to know of any benign disorders that can change your blood labs like this.
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