Total Protein

[nved]

I have ulcerative colitis and i had the following blood work which showed:

WBC 9.59 (3.8-10.5)
NE# 5.2 LY# 3.52 MO# 0.73 EO# 0.14 BA# 0.04 NRBC #0
RBC 4.78 (4.20-6.30)
HGB 16.4 (14.0-18.0)
HCT 48.6 (40-52)
MCV 101.60 HIGH MCH 34.2 HIGH MCHC 33.7 RDW 13.8%
PLT 271

Calcium, Total 10.2 (8.8-10.6)
Total Protein 8.2 (6.6-8.3)
Albumin 4.4 (3.5-5.2)
ALP 81 (30-120)
LDH 250 High (0-248)
Iron 178 (70-180)
Ferritin 42 (22-322)
B12 214 (211-911)
Folate 4.2 Low (>5.38)

CRP 3.19 (<5)
ESR 5mm/hr

TSH 2.64 (0.4-4.0)
Free T4 0.70 Low (0.84-1.76)

What im worried is the level of Globulin because total protein 8.2 - Albumin 4.4 = 3.8
Could the ulcerative colitis as an autoimmune disease elevate globulin levels?
Also I'm waiting for results on Antinuclear Ab and Anti-TPO/Anti-TG Antibodies. (HIV,HCV,HBV negative)

[nved]

I had the test done again in another laboratory and it was Total Protein 7.0 Albumin 5.1 & Globulin 1.9

[Dr. Kokil Mathur]

Hi!

Yes, conditions like autoimmune disease, MUGS, multiple myeloma can raise the globulin levels. In your case, chances of autoimmune disease are more as other blood tests are normal. The only other finding is low folate. Low levels can be due poor intake of folic acid rich food (green leafy vegetables, yellow fruits, avocado, beans, lentils, cauliflower etc) or due to malabsorption syndromes (IBS, tropical sprue, Crohn’s, celiac etc) or due to eating disorders causing malnutrition.  
Since a confirmed diagnosis cannot be given on net please consult your doctor regarding this. Hope this helps. Take care!

The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you. The advice may not be completely correct for you as the doctor cannot examine you and does not know your complete medical history. Hence this reply to your post should only be considered as a guiding line and you must consult your doctor at the earliest for your medical problem.

[nved]

Also total calcium is 10.2 which if corrected for my albumin is:
10.2 - (0.8 * (4.0 - 4.4) = 9.88 right?

[nved]

To add something, i had the Total Protein/Albumin test 2,5 years ago and the levels were
Total Protein 8.7 Albumin 5.2 Globulin 3.5 So Globulins are elevated by 0.3g/dL.