Cold ankles with leg pain can happen due to peripheral vascular disease or disorder of the circulatory system outside of the brain and heart (such as venous pooling or deep vein thrombosis). Other causes of cold ankles with leg pain are hypothyroidism, eating disorders like anorexia, Vit B12 deficiency, Addison’s disease, adrenal causes like pheochromocytoma, anemia, Buerger’s disease, chronic fatigue syndrome and Raynaud’s disease. Your daughter will need some tests like treadmill test, color Doppler, angiography, ultrasonography and MRI (magnetic resonance imaging).
Since I cannot examine your daughter and know other related conditions she may be having, nor is a detailed history possible on net, I have listed the various possibilities that should be looked into. Please consult your PCP for primary examination followed by proper referral. Take care!
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