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pernicious anemia-autoimmune anemia? instead of just iron deficient?
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pernicious anemia-autoimmune anemia? instead of just iron deficient?

i have autoimmune thyroid (and some  other autoimmune disorders-raynauds, lsh) and Anemia. my question-i;ve been on 1000% iron replacement tablets for 2 years and still need to take them to stay within borders.  but my RBC was low-and the new creation of cells was at zero percent when i understand it should have been high with high iron replacement. i think somthing else is going on except heavy bleeding which i do NOT do (i'm 40 and have very little periods) . Pernicious anemia possible? or something else? im scandinavian background, and the autoimmune thyroid...
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Vitamin B12 deficiency can be seen with:

* Decreased vitamin B12 serum - serum reference range is far too low in most countries however. Japan and Europe increased the lowest acceptable B12 serum to 500 or 550pg/mL.

* Elevated methylmalonic acid (MMA) - methylmalonic acid rises just 10 days after a B12 deficiency starts. MMA is a sensitive and early indicator of vitamin B12 deficiency. Urinary MMA more accurate than a blood MMA test.

Elevated homocysteine.

Elevated holotranscobalamin.

After confirming a B12 deficiency, testing for parietal cell antibody and intrinsic factor antibody is recommended based on your risk factors**.  

Iron deficiency is very common with celiac's disease. Research reported in the medical journal "Digestive Diseases and Sciences", a significant number of patients with autoimmune thyroid disease have celiac disease.  Some people with celiac disease have no symptoms.

**Risk factors for autoimmune pernicious anaemia include:

* Your risk increases with age:

- 1 in 1 000 people (1000 in 1 million) over the age of 60 develop pernicious anaemia

- 1 in 10 000 people (100 in 1 million) under the age of 40 develop pernicious anaemia

* Female

* Family history of the disease - 3 out of every 10 people who have autoimmune pernicious anaemia, someone else in their family also has the condition

* History of autoimmune endocrine disorders, including: Addison's disease, Hashimoto's Thyroiditis, Graves disease, Hypoparathyroidism, Hypopituitarism, Myasthenia gravis, Type 1 diabetes, Vitiligo

* Blood type A

* Blue eyes

* Scandinavian or Northern European descent
I was finally able to get dr to listen-did gastro test and found
autoimmune gastritis which means body cannot keep b12  also
have hashimoto like you mentioned and am scandinavian. i think they did a
homocysteine test will check.  thank you for the values of 500 plus-did b12 in 2008 and it was "OK" acc to here at 430. i am afraid if do another blood work they'll say is above 200 so ok... any suggestions.
i could do the b12 shot before the blood work...
I have autoimmune pernicious anaemia (positive intrinsic factor antibodies and positive parietal cell antibodies).  I take sublingual B12 spray daily - 2000mcg. My symptoms return within 3 days if i don't take my sublingual B12 spray!

I read your other question "lupus or connective tissue disease".  I had lupus like red rash on my face that lasted for an hour or so but only after a shower. A random symptom that i have had for over 4 years with no explanation. Another symptom was splinter haemorrages on my nails that came and went again with no explanation.

It was only when these two symptoms worsened dramatically during a two month hashitoxicosis flare up (i too have Hashimoto's thyroiditis) and i realised these were both a symptoms of a hyperthyroid flare up (extremely mild to moderate/severe).

The following excerpt is from the book "The Everything Guide To Thyroid Disease" by Theodore C. Friedman, MD, PhD and Winnie Yu Scherer...

"Although the majority of people with Hashimoto's will not develop any other disorders, it's important to know what some of these autoimmune conditions are in case you do start to experience symptoms. Keep in mind, too, that you may be more likely to develop Hashimoto's if you have one of these other conditions.

Type 1 diabetes
Pernicious Anaemia
Addison's Disease
Celiac Disease
Alopecia Areta
Systematic Lupus Erthematosus (SLE)
Rheumatoid Arthritis
Sjogren's Syndrome
Inflammatory Bowel Disease
Multiple Sclerosis (MS)"
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