Either an inner cheek swab or a blood sample will be requested from siblings and occasionally from parents.
We start off with checking whether a sibling is a possible match. Each sibling has 25% chance of being a perfect match. If your grandson has more than one sibling, the chance that he will have a sibling match is higher.
There is less than 5% chance that a parent would be a perfect match. We do not check extended family members .
If there are family members that are perfect matches, we then search for unrelated donor or umbilical cord blood units that may be a source of stem cells..
If no sibling donor, unrelated donor, or umbilical cord blood unit match can be found, at some institutions, a "haploidentical" transplant can be performed in which case a parent ("half-matched") is the donor.
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