medications used to block FSH and LH secreting hormones

[MyDaughtersAdvocate]

Can you please advise on the types of medications available on the market today to block FSH and LH secreting pituitary adenoma’s for a child (8 years old girl and 50 lbs.).  My daughters endocrinologist wants to put my daughter on 11.25 mg shots of Lupron Depot PED monthly – in hopes of shrinking a 4x4x3 pituitary tumor and blocking hormones that are causing my daughter to experience true precocious puberty.  I am very concerned with #1 the drug and #2 the dosage.  My current endocrinologist has never treated a child with this scenario and this dosage amount.  Please advise.

[rumpled]

Yeah!
All these meds are for fertility - I found NO usage for pituitary treatment. When I searched for that I got zilch...

[MyDaughtersAdvocate]

Thank you very much for your response.  I will research these medications further.

Note:  I did reach out to NIH and was able to speak with Meg yesterday regarding my daughters issues.  I am trying to get more copies of the last MRI then will package and send off.

[rumpled]

From a search it seems to be Lupron, Antagon and Cetrotide. The latter are newer medications.

"Lupron is a GnRH agonist and it impedes the production of GnRH at the hypothalamus. When GnRH is suppressed, the body’s production of natural FSH by the pituitary slows and external FSH must be administered to stimulate follicular development. "

"Ganirelix and Cetrotide produce the same physiologic effects of GnRH suppression as Lupron.   However, these products actually block GnRH at the pituitary producing a “more complete” suppression. Because of this blocking effect, more FSH  is sometimes required for Ganirelix/Cetrotide suppressed cycles. Also, these products can be given for a shorter time than Lupron increasing patient convenience."

Side effects of cerotide:
"Approximately 3.5 % of female patients treated with cetrorelix have developed ovarian hyperstimulation syndrome (OHSS). Symptoms of OHSS include severe pelvic pain, swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, low urine output, diarrhea, and nausea or vomiting. OHSS can be fatal. Notify your doctor..."
I did not see any side effect relative to pituitary or pituitary apoplexy though...

Antagon was like this:
"Some women using this medicine have developed a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment cycle. OHSS can be a life-threatening condition. Call your doctor right away if you have any of the following symptoms of OHSS:

    * severe pelvic pain;
    * swelling of the hands or legs;
    * stomach pain and swelling;
    * shortness of breath;
    * weight gain;
    * diarrhea;
    * nausea or vomiting; or
    * urinating less than normal.

Less serious side effects may include:

    * pelvic pain (similar to menstrual cramps);
    * mild nausea or stomach pain;
    * headache;
    * vaginal bleeding; or
    * pain, redness, or irritation at the injection site."
They are all on the infertility sites - and the later drugs seems to be preferred now over lupron...