I am assuming that TLC is the total lymphocyte count. If so, it sounds like your brother suffered from a post-operative infection. Infections are a risk from surgery and often time need to be treated with antibiotics. By the TLC going down, it is likely indicative of a infection responding to the antibiotics. Your doctors may be waiting to operate to see if the infection can be treated effectively enough by the antibiotics to avoid having to remove his bone. In terms of CSF being discharged from the brain, I assume they are using a little cathetar to divert the CSF away from the head to allow for the incision to heal. Patients can sometimes have headaches due to the drain or from the infection.