HER2 Equivocal, E-cahedrin positive and negativ

[starsouler]

I had a right modified radical mastectomy in March 2009, followed: by 4 cycles of AC regimen; 1 cycle of taxotere (had severe toxicity reaction); 1 cycle of Abraxane (severe peripheral neuropathy, palmar-plantar dysesthesia,nail changes/loss); completed regimen with 2 more cycles of Abraxane at reduced dosage. Pathological staging: pT1bpN2apMX; stage IIIIa. DX AFTER MASTECTOMY: Invasive breast carcinoma (multifocal) with ductal and lobular features and multifocal DCIS; tumor site - Central (Subareolar), Lower outer, Upper inner: multiple, small simultaneous ipsilateral carcinomas, Nottingham Histo score 7, Grade II. 7 of 20 Lymph nodes w/ micrometastases at least 1 > 2.0mm. ER/PR - (90%) positive; FISH -  Her2 e-cahedrin negative ratio Her2(Avg 1.9) to D17Z1(Avg1.6) signals = 1.2 and multiple cells showed fewer than 2 copies HER2 and centromere (D17Z1 control probe) signals for chromosome 17 (suggestive of monosomy chromosome 17. My Original Dx RIGHT BREAST BIOPSY ( done by a different lab) - HER@ FISH Results: ER/PR 90%, positive; HER2 & CEP17 FISH - 1.9 equivocal, E-Cahedrin positive, Avg HER2 - 4.33, Avg CEP 17 - 2.27 (results were verified by 2 observers. 1.My question is - Should I be treated with Herceptin also due to the original Biopsy pathology is E-Cahedrin positive, with gene amplification. (The Mastectomy Biopsies had no amplification but with monosomy 17.)? (I am also having 33 radiation treatments beginning this Thursday and have just started taking Tamoxifen (last Chemo was Sept 23,2009).) Thank you for your help. I am worried because of a negative Mammo June 2009, then Lump in NOV., 2009 and Dx of breast cancer in DEC & verified FEB 2009, surgery March 2009, My cancer went from Stage1 to Stage 111a quickly(to me), and I really would not like to get an additional Dx of HER2 positive in the future. Thank you sincerely for your time, Hope

[japdip]

First I would like to suggest that you post this concern on the "Expert" Forum (Breast Cancer) for an opinion from the Med Help Physicians.
"E-cadherin expression is frequent in invasive ductal carcinomas that progress to develop distant metastases. Distant metastases consistently express E-cadherin, often more strongly than the primary tumor. Invasive lobular carcinomas have a different pattern of E-cadherin expression, suggesting a different role for E-cadherin in this form of breast carcinoma." This protein is found in epithelial cells.
As far as a comparison between E-Cad and Her2;I have no information concerning this relationship.

[bluebutterfly2222]

And before you post there, you might want to recheck some of the dates you listed.( I assume you meant neg mammo June 2008, lump Nov. 2008?)

Regards...

[starsouler]

Thank you for your time and information. It is sincerely appreciated. I am new to MedHelp and will post my concerns to the BC Expert Forum. Sincerely, Hope

[starsouler]

You are correct, Neg Mammo June 2008, Found lump Nov 2008. Thank you for correcting me. Sincerely, Hope

[SueYoung55]

Here is the link to the expert forum. They do answer questions daily.

Best wishes!

http://www.medhelp.org/forums/Breast-Cancer/show/121