? about adjunctive Rx for BC with history of heart surgeries

[LJCthemom]

In Oct. I was dx with increased # of linear microcalcifications. Biopsy showed ADH. Now having excisional biopsy of site.  From what I see in forums I could expect to be put on some sort of Chemo/Hormone therapy as adjunctive TX. I've had 3 open heart surgies for a congenital defect. Residual regurgitation at all valves, pulmenary stenosis, occasional arrythmias. Also Pre-menopausal.  What if any meds would be "safe" for me to take?  What are alternatives if medication is deemed too risky?  Where would I get specific information about the various drugs used?  I've had to make decisons re: the previous procedures with no prior info. and only research after.  I'd like to be more proactively informed on this next possible step. Thanks so much.

[CCF-RN,MSN-rf]

Dear LJCthemom:  The recommendations for further treatment will depend upon the results of the excisional biopsy.  If there is nothing other than ADH, this is not cancer but does increase your risk for developing breast cancer in the future.  Research has shown that some medications such as tamoxifen or raloxifene can decrease the risk of developing breast cancer in high risk women. While tamoxifen has been studied in both premenenopausal and postmenopausal women at risk for breast cancer, raloxifene has only been tested in postmenopausal women. Both drugs can increase the risk blood clots and stroke. Taking any medication must take into consideration benefits versus risks as they pertain specifically to you.  Certainly, your cardiologist should be involved in any discussion if preventive treatment is recommended.  

If however, the excisional biopsy has a different result, any recommendations would be based on the new information.  It is too soon to speculate on what the next steps will be.