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Hi Sue..I've been taking Arimidex since last November and I did not gain any weight.The only side effects that I noticed lately is that I feel a littleLittle noses decongestant Little tummys depressed ( I don't know if this is due because of the Arimidex) and loss of appetite.Maybe if I start eating a bit more I could gain some weight.My sister who is a bit older than me, has gained about 5 pounds in almost 2 years with TamoxifenTamoxifen Tamoxifen citrate; soon she will start Arimidex too and we'll see what side effects she'll have.The only good thing I can say for now is that I don't have any hot flashes, but unfortunately my sister does.I guess we all react differently when taking any kind of medicines.