I am 50 years old, premenopausal DX. Stage 1, IDC, SNnode neg. ER/PR+, HER neg. , .8cm tumor removed-lumpectomy, Histologic grade III/ III (slight or no tubule formation) , nuclear grade II/III , medical oncologist says decision is mine to treat with 8 cycles of CMF every 21 days. 2 aunts premenopausal had breast cancer, one mothers sister and one fathers sister. One survived the other died before 5 year mark. Pathology report also noted removal of DCIS and 2 papillomas and a fibroadenoma, ductal hyperplasia with and without atypia, columnar cell changes, sclerosing adenosis, cystic formation and stromal fibrosis. Would chemo be beneficial? Will undergo radiation with or without chemo.
Dear backcracker, Decisions about adjuvant chemotherapy or hormonal (antiestrogen) treatment are based on several factors including size of tumor, status of lymph nodes, the appearance of the cancer under the microscope, the presence or absence of hormone receptors for estrogen and/or progesterone, as well as HER2 status, the general health of the patient etc. We can not make specific treatment recommendations for an individual in this forum. We can tell you that antiestrogen treatments are frequently given following surgery for ER/PR-positive breast cancer to reduce the risk of recurrence in the form of metastatic disease. Chemotherapy may add an additional benefit that needs to be weighed against the potential side effects. In some situations where the additional benefit of chemotherapy to endocrine therapy is unclear, a test called an Oncotype DX can be helpful in determining prognosis with endocrine therapy alone and the likelihood that chemotherapy would add further benefit.
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