DCIS WITH ER/PR- & HER2/NEU +

I AM 57 YEARS OLD , & CONFUSED  IF I AM IN THE CORRECT DIRECTION?? I HAVE THE FOLLOWING RESULTS & MY DOCTOR  DID NOT GIVE ME ANY MEDICATIONS & TREATMENT.

On Sept. 6,2007  I have excision on my left breast the following findings:

1) SURGICAL PATHOLOGY CONSULTATION REPORT

GROSS DESCRIPTION:
Specimen consists of a 2.3x2.5x1.3cm irregular whitish tan doughy tissue fragment with firm areas interspersed with some small cyst.
MICROSCOPIC DESCRIPTION:
Sections reveal a ductal carcinoma consisting of neoplastic ducts presenting comedo, cribriform and occasional solid patterns. Several ducts show tumor cells with apocrine features. There are no invasive tumor cells seen.
HISTO-PATHOLIGICAL DIAGNOSIS:
-DUCTAL CARCINOMA IN-SITU, LEFT BREAST



2) 2nd opinion On September 13,2007
  
SURGICAL PATHOLOGY CONSULTATION REPORT
Diagnosis:
Left Breast Mass
   DUCTAL CARCINOMA IN SITU, NUCLEAR GRADE 2-3,
   IN CRIBRIFORM, SOLID AND COMEDO PATTERNS.

Gross/Microscopic Description:
GROSS: Received in consultation is a slide with its corresponding paraffin labeled 2007 9844.



3) On September 11,2007: IMMUNOSHISTOCHEMISTRY REPORT

Estrogen Receptor Assay= NEGATIVE
Staining Intensity= 0
Percent tumor cells stained= 0

Progesterone Receptor Assay= NEGATIVE
Staining Intensity= 0
Percent tumor cells stained= 0

P53 POSITIVE
c-erbB-2 (HER-2, Neu) POSITIVE






4) On September 13,2007 :

FLOW CYTOMETRY DNA CONTENT AND CELL CYCLE ANALYSIS

RESULTS: An aneuploid DNA content is observed.

DNA Index: 1.0
Percent of Total: 82.745%
G2 Phase: 0.885%
S Phase: 0.000%
Aneuploid Cells: 1
DNA Index: 1.6106
Percent of Total: 17.255%
G2 Phase: 2.155%
             S Phase:15.017%

INTERPRETATION:
Breast carcinomas with an aneuploid DNA content have been associated with higher histologic grade and worse prognosis (Cancer 65 (10): 2315, 1990: Int. J. Cancer 45 (1): 34, 1990). The S Phase of this tumor is High, which places it into a less favorable prognostic category and this is a stronger prognostic factor than ploidy in both node negative and positive cancers. (Br. J. cancer 62 (5); 786, 1990; J. Clin. Oncol. 8 (12); 2040, 1990; NEJM 322 (15); 1045, 1990; DNA Cytometry Concensus, Ctytometry 14 (5); 482, 1993).


On Sept. 19, 2007: I HAVE MASTECTOMY of left breast & FF THE FINDINGS:

SURGICAL PATHOLOGICAL CONSULTATION REPORT


GROSS DECRIPTION:

Submitted is a modified radical mastectomy specimen of the left breast which weighs approximately 400 grams and measures 17.5x18x3cm the ellipsoidal fragment of the skin which measures 14.5x5x5cm shows a 3.5cm long healing wound at the upper inner quadrant 1.5cm from the nipple. The later measures 1.0cm wide. It is devoid of any surface lesions. Serial sections of the breast disclose an ill-defined firm nodule measuring 0.7cm wide at  the biopsy site. Lines of resection are free.Lymph nodes are recovered from the attached axillary fat and separately submitted axillary dissection specimens labelled “I” and “sentinel.” The three sentinel nodes range from 0.5-1-.5cm in diameter.



MICROSCOPIC DESCRIPTION

At the previous biopsy site is a solitary residual island of ductal carcinoma cells trapped within a fibrous scar tissue. Around the area is fat necrosis and chronic inflammation. The nipple is essentially normal.

Three “sentinel” and twelve Level I lymph nodes are negative for tumor.
  

HISTO-PATHOLOGICAL DIAGNOSIS:

-DUCTAL CARCINOMA, RESIDUAL, UPPER INNER QUADRANT, LEFT BREAST, FIFTEEN (15) AXILLARY LUMPH NODES, NEGATIVE FOR METASTASIS.

On September 28,2007 I have test  for;

CHROMOGENIC IN-SITU HYBRIDIZATION (CISH)

c-erbB2 (Her-2/neu) POSITOVE (High Amplification)