DOSE DENSE REGIMEN

I am a 38 year old female with a 1.7CM Infiltrative Ductal Carcinoma high Grade II(Tubile Formation:3; Nuclear Pleomorphism: 3; Mitotic Score: 1):Inavsive 75%; Intraductal Carcinoma In Situ: 25%. Margins: Negative; HER-2 negative (FISH Test) and Estrogen and Progesterone Positive. Pathology Reports were completed by Bridgeport Hospital, Dana-Farber and Weill Cornell (3 opinions, all agree). Completed a lumpectomy on 5/18/04 and Sentinel Lymph Node/Lymph Node Dissection on 6/3/04.
Two Lymph nodes were positive and removed. Left Axilla, Sentinel Node Dissection: Metastic Adenocarcinoma involving 2 out of 4 nodes; Largest positive node measures 1.6CM in diameter with focal extranodal extension. Left Axilla Dissection: No metastasis in 8 lymph nodes. According to Dana-Farber: there was no extranodal invasion and the carcinoma would be classified as AJCC (6TH Edition): T1b N1 (sn) MX.
We visted our local oncologist and received a second opinion at Dana-Farber in Boston. Both oncologists proposed Adjuvent chemotherapy using a dose dense regimen of AC followed by T. The standard being AC every two weeks for 8 weeks and then T every two weeks for 8 weeks. (16 weeks total). The local oncologist has been using a dose dense regimen of AC every two weeks for 8 weeks followed by T weekly for 8 weeks, instead of T every 2 weeks. Dana-Farber didn't have a problem with this difference as long as it doesn't go to the 3 week regimen. Dana-farber uses T weekly for patients with more advanced cancer.What do you think of the AC followed by T weekly in my case?

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Dear EXTEL PRES:  To date there is no research that compares dose dense (every 2 week taxol) to dose dense (weekly taxol). So, there is no easy right answer.  Certainly, both are used in practice with success, although I am not aware of weekly taxol being used routinely in the dose dense arena - as dose dense therapy is pretty new as a treatment regimen.  You will probably not go wrong with either option.