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Hi. Some chemotherapeutic drugs can cause nail discoloration. The nails can also get dry and brittle and flake off, although this does not happen often. These conditions are temporary and will slowly disappear after the last cycle of chemotherapy is finished. You can try using moisturizing creams to avoid nail flaking. You can also apply some nail polish if the discoloration really bothers you.
a friend of mine who has already gone thru chemo lost her big toe nail and 2 finger nails due to chemo...honestly, i dont know if they turned black first or not....id just keep them trimmed as short as possible and be careful not to snag them on anything....