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Breast Cancer (Expert Forum)
Her2positve w/ estrogen § progesterone positive and scared
Questions posted in the Breast Cancer Forum are answered by medical professionals from The Cleveland Clinic. Topics include Breast Biopsy, Chemotherapy, Hormone Therapy, Lumps, Lumpectomy, Lymph node dissection, Lymphedema, Mammograms, Mastectomy, Radiation Therapy, Reconstruction, Self Breast Exam, and Surgery.
Her2positve w/ estrogen § progesterone positive and scared
by POPro, Dec 15, 2002 12:00AM
what is the prognosis for this type breast cancer, and what would be the best chemo treament for me. I/m 47, and literally scared to death. My first surgery on 11/14/02 revealed: Infiltrating ductal carcinoma, poorly differentiated grade 3/3, 0.7cm size invasive tumor present at the medial margin. Intermediate to high grade, solid type with comedo necrosis, 1mm present at the medial margin. One lymph node out of 4 positive for metastatic carcinoma. some tumor cells detached from the lymph node. Tubules=2of3, Nuclei=3of3,Mitosis=3of3. Both invasive and in-situ tumor present at the medial margin.
Estrogen Receptor:90%, Progesterone Receptor:70%, Ki-67 30%, and is Her2 positive. 2nd surgery was done on 12/4/02 to clean up margins, take all lymph nodes and extra tissue. what are the chances of the chemo will get what is ever left if anything. have not got the path report back from the second surgery. Would you consider trying Herceptin with Aridemex as a adjuvant treatment. please help, don't know where to go with this, is this fatal. Want to be proactive in my treatment, but need to understand exactly what all this means to be proactive. My surgeon is great, has done a remarkable job on the incision but not a talker.This does not run in my family, I am it.
Estrogen Receptor:90%, Progesterone Receptor:70%, Ki-67 30%, and is Her2 positive. 2nd surgery was done on 12/4/02 to clean up margins, take all lymph nodes and extra tissue. what are the chances of the chemo will get what is ever left if anything. have not got the path report back from the second surgery. Would you consider trying Herceptin with Aridemex as a adjuvant treatment. please help, don't know where to go with this, is this fatal. Want to be proactive in my treatment, but need to understand exactly what all this means to be proactive. My surgeon is great, has done a remarkable job on the incision but not a talker.This does not run in my family, I am it.
Doctor's Answer
by CCF-RN,MSN-JS, Dec 16, 2002 12:00AM
Dear LMF, With the presense of cancer in the lymphnodes, adjuvant chemotherapy would be the standard of care. (The actual stage of your cancer would be determined after the results of this second surgery are in). Combination chemotherapy (use of more than one type of chemotherapy) most likely will be recommended, and the combination will take into account your overall health and individual situation. Based on the second surgery (if this was a mastectomy or not) would determine if radiation would be done (if lumpectomy - yes, if mastectomy - maybe). Your hormone receptors are positive, so adjuvant hormone therapy would be recommended. The current standard of care is use of tamoxifen, arimidex is used in treatment of post-menopausal women for treatment of metastatic disease, although it is currently being studied more in terms of long term results as adjuvant hormone treatment. Herceptin is used in treatment of metastatic breast cancer that expresses a positive Her-2neu receptor, it's usefulness in terms of adjuvant therapy is currently being studied.
You will be referred to a medical oncologist who can help you in terms of sorting out as to what the best treatment plan would be for you. Also they would be able to advise you as to whether you there are available clinical trialsin your area, that are looking into answers to some of the arimidex and Herceptin questions, and whether you may be eligible to participate if you so choose.
You will be referred to a medical oncologist who can help you in terms of sorting out as to what the best treatment plan would be for you. Also they would be able to advise you as to whether you there are available clinical trialsin your area, that are looking into answers to some of the arimidex and Herceptin questions, and whether you may be eligible to participate if you so choose.
