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Breast Cancer (Expert Forum)
Low-dose CMF
Questions posted in the Breast Cancer Forum are answered by medical professionals from The Cleveland Clinic. Topics include Breast Biopsy, Chemotherapy, Hormone Therapy, Lumps, Lumpectomy, Lymph node dissection, Lymphedema, Mammograms, Mastectomy, Radiation Therapy, Reconstruction, Self Breast Exam, and Surgery.
Low-dose CMF
by Franciscus, Aug 14, 2005 12:00AM
Does anyone have any current information on the effectiveness of low-dose, weekly, CMF? It has ben suggested for my wife, and we are trying to do some research on this. Thanks.
Doctor's Answer
by CCF-RN,MSN-rf, Aug 17, 2005 12:00AM
CMF is a combination of three chemotherapy drugs: cyclophosphamide, methotrexate and 5-fluorouracil. There are several different schedules on which these drugs may be given. In the postoperative treatment of early breast cancer, the "classic" regimen includes 14 days of cyclophosphamide and intravenous methotrexate and 5-fluororuacil treatment given on day 1 and day 8 of each 28 day cycle. Variations of this regimen, such as lower-dose weekly administration may be used in situations where the goal is to limit toxicity (side effects) from the chemotherapy.
