BREAST CANCER EXPERT FORUM
Nuclear Grade?

Nuclear Grade?

My path report says that I have a poorly differiated tumor at grade 3.  I took my slide to UCLA and they said  that I had a low to intermediate nuclear grade?  What is the difference because I am confused?

thanks
becky
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Dear Becky, Grading system is a way of classifying tumors by their appearance under the microscope.  A "high-grade" tumor is immature, poorly differentiated (looks less like the normal cell that it originated from), fast growing and aggressive.  A "low-grade" tumor is usually mature, well-differentiated (looks similar to the normal tissue that it originated from), slow growing and less aggressive.  It is not unusual for two different pathologists to have different opinions regarding the grading of a tumor.  The information about tumor grading is only one of the factors used by the physician in making decisions regarding recommendations for adjuvant treatment for breast cancer.
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