Receptors

What does ER/PgR: Positive (95%)/Positive (18%)
and Her2: 3+, Positive mean


This discussion is related to high-grade DCIS with microcalcifiacations.

[bluebutterfly2222]

Hi and welcome to our community!

ER and PR are parts of your cancer's "hormone receptor status."  ER+/PR+ is considered favorable, because there are targeted treatments (tamoxifen and AIs) for it, which can significantly reduce your risk for recurrence.


HER2+ status is a concern, because this indicates an aggressive type of BC with an increased risk of recurrence. For this reason, the latest view is that even small HER2+ tumors call for tx with both chemo and Herceptin (a targeted tx for HER2+ BC).

"From the San Antonio Breast Conference in December, new data shows a higher than predicted rate of breast cancer recurrence even with very small breast cancers that are HER2 positive. The data is from the first large study to analyze early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller. All these women would benefit from adjuvant Trastuzumab, also known as Herceptin, (for one year, the standard in America) -- along with adjuvant chemotherapy. This represents a shift in the way women with early-stage HER2 positive breast cancer should be assessed for risk of recurrence and considered for treatment, according to the study's author."

However, chemo probabaly won't be recommended in you case if you have only been diagnosed with DCIS (ductal carcinoma in situ), and not IDC (invasive ductal cancer).

Best wishes...

[b41950]

My cancer was DCIS with a size of less than1.5 cm but was high grade nuclei with comdeo from what I can find HeR2 number isn't of much use in DCIS