Removal of Ovaries after Recurrence

[susie228]

In 2007 I had a lumpectomy (1.9 cm tumor - ER positive, Her2 negative - negative for BRAC gene) I underwent radiaton and was put on tamoxifen. Two months ago I discovered a very small lump in same breast - turns out it was another tumor - 3mm in size. I just had a double mastectomy and now my doctor is recommending removal of my ovaries. (My mother had inflammatory breast cancer four years ago - she is okay and there is no other breast cancer in our family history)
I just learned about a new study regarding tamoxifen and antidpressants (how paxil and zoloft have an adverse affect on tamoxifen) I have been on both (first zoloft - then paxil) and think this may have contributing to my recurrence. I am 46 and not really looking forward to the immediate onset of menopause that would come with ovary removal, but of course will do it if it the best option.

Any advice?????

[susie228]

Thanks Sue. I know that it will lower the risk - but I am just hesitant because of the immediate onset of menopause (not that I am so far away from it anyway!) I am just going to keep investigating until I feel confident enough to make an informed decision.

[SueYoung55]

The two antidepressants you mention are part of the SSRI group that kept the tamoxifen from working to it's full potential. I take Lexapro and don't have a problem with the combination.

I'm not sure why they are suggesting an ooph for you but if you're open to the suggestion, it will lower your risk of ovarian cancer.

Best wishes and I'm sorry you had a recurrence. That's probably my biggest fear/nitemare.