Dear Jazamine: It is not uncommon for a spot on a mammogram to go away with compression. Usually, it's an indication that all is okay. However, in your case, an ultrasound was done. If there is a spot on the ultrasound, and it does not appear cystic, then it makes sense to biopsy. Perhaps, for the sake of not sending you home, they can do an ultrasound guided biopsy, since this "spot" does not show up on a mammogram. If you are uncomfortable, you can also take all of your films and get another opinion.