BREAST CANCER EXPERT FORUM
What to do now??

What to do now??

Have just had a lumpectomy & 2 sentinal nodes removed.  Am node -ve; though some reactive histiocytes with nuclear variation & macronucleoli found in 1 node.
Pathology:Infiltrative ductal type carcinoma with ragged nests & cords of infiltrating tumour focally present within fibrous stroma. Within the area of invasive tumour are areas of high grade duct carc in-situ with central space necrosis but a significant spread beyond the areas of invasive tumour. Tumour cells show moderate to large size with moderate eosinophilic cytoplasm. Nucleii show moderate to severe nuclear pleomorphism with some focal tubule formation & high grade mitotic activity. Adjacent breast tissue shows some fibrous & mild blunt duct adenosis. Size 30mm. Nottingham grade III (score 8/9, nuclei 3, mitosis 3, tubules 2). Margins -ve.
Some areas of in-situ high grade duct carcinoma in-situ present in area of invasive tumour but no significant duct carc in-situ beyond invasive tumour. Focal intralymphatic permeation seen. ER moderate +ve. PR mod +ve. c-erbB-2 -ve.
An irregular piece of fatty tissue also removed shows fatty tumour without malignancy.
Should we seek a 2nd pathology evaluation? Should we request other factors (cathepsin D,epidermal growth factor,heat shock protein,etc)?
Is Chemo a must? Tamoxifen? What about Aromatase inhibitors?  Iressor? Is ovarian suppression a must with endocrine therapy?  What about combinational endocrine therapy's? Other new drugs/treatments?  What are our maximum treatment options & stats without chemo & ovarian suppression but using everything else available?
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