Dear Kimber, Current research has shown superior tumor control and overall survival rates with the addition of post-mastectomy radiation therapy, for women at high risk for tumor recurrence. This high risk group includes women with four or more positive nodes or an advanced primary tumor. In the same analysis of the data there was also noted a higher risk of arm swelling (lymphedema). At this time, the role of post-mastectomy radiation therapy for women with one to three positive lymph nodes remains uncertain and is being examined in a randomized clinical trial.
Radiation therapy if given should not be given at the same time as the chemotherapy and should be delivered within the first 6 months following mastectomy.
This information is from the National Institute of Health Consensus Statement regarding adjuvant therapy for breast cancer, December 2000.
Continue your discussions with your oncologist so that you can weight the risks and benefits that are specific to your case.