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It all depends on how you react to pain or discomfort. Some womenWomen's way find these injections quite painfulPainful menstrual periods and others only experience mild discomfort. Some type of numbing medicine is used and the discomfort is more from the amount of fluid that is injected rather than the isotopePet scan itself. I would suggest you make it clear to the Radiologist that you have a rather low pain threshold well in advance of your appointment. Regards .....