recurrence invasive ductal carcinoma

After having a lumpectomy, chemo and radiation my wife is 2 1/2 years out from treatment and has a recurrence. She is scheduled for a mastectomy. What type of follow up treatment is availible?

Her 1st tumor was said to be Her2neu hormone neg and her current tissue is said to be her2 neg and hormone positive, is this possibl?

[CCF-RN,MSN-JS]

Dear tmouse, The treatment of recurrent breast cancer varies depending on where the cancer has recurred.  
The current standards are: If there is no internal disease and recurrence is confined to the area of the original tumor, surgery and/or radiation therapy is used, plus tamoxifen in selected cases.  If there is no life-threatening disease involving major internal organs, if there has been at least 2 years since mastectomy and positive hormone receptors, the standard treatment is tamoxifen or removal of the ovaries in premenopausal women.  If patients respond to hormonal therapy and then relapses, other forms of hormonal therapy are used.  If major internal organs such as the liver are involved chemotherapy is usually given.  The type of chemotherapy/combinations varies.  Your surgeon and oncologist will discuss their recommendations with you and your wife based on the specifics of your wife